Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6502-5. doi: 10.1002/anie.201201812. Epub 2012 May 29.
Making a comeback: The inefficient condensation of sulfinic acid and aryl nitroso compounds has been transformed into a chemoselective process that converts sulfinic acid into stable cyclic sulfonamide analogues (see scheme). This ligation proceeds rapidly under aqueous conditions in high yield, and lays the groundwork for the development of sulfinic acid detection methods in biological systems.
磺酸和芳基亚硝化合物的低效缩合已转化为一种化学选择性过程，可将磺酸转化为稳定的环状磺酰胺类似物（见方案）。该连接在水相条件下快速进行，产率高，为在生物体系中开发磺酸检测方法奠定了基础。
