Dolens Eder da Silva, Nakai Fabrícia Venâncio Dolens, Santos Parizi José Luiz, Alborghetti Nai Gisele
Dentistry School, University of Western São Paulo (UNOESTE), Presidente Prudente, SP, Brazil.
Diagn Cytopathol. 2013 Jun;41(6):505-14. doi: 10.1002/dc.22875. Epub 2012 May 30.
Oropharyngeal cancer is the 11th most common cancer worldwide. The diagnostic method of choice for oral cavity lesions is biopsy and pathological examination. Cytopathology is a simple and inexpensive method, but it is not yet widespread among dental professionals. The aim of this study was to evaluate the evidence for the effectiveness of cytopathology in diagnosing oral lesions. We conducted a systematic literature review of randomized clinical trials that compared the diagnostic accuracies of oral lesion cytology and histopathology. We used the following search terms: cytology, oral lesions, and oral cancer. The meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Between 1967 and 2010, there were 80 relevant articles in the literature, 14 of which were included in this study. The I-square for sensitivity was 80.2%, and the specificity value was 96.7%. The pooled sensitivity was 0.942 [95% confidence interval (CI): 0.926-0.955], and the pooled specificity was 0.970 (95% CI: 0.963-0.975). The area under the curve was 0.9901. Our study suggests that cytology has good sensitivity and specificity for the diagnosis of oral lesions and allows the use of other associated techniques, such as DNA analysis, which may improve the accuracy of cytology.
口咽癌是全球第11大常见癌症。口腔病变的首选诊断方法是活检和病理检查。细胞病理学是一种简单且成本低廉的方法，但在牙科专业人员中尚未广泛应用。本研究的目的是评估细胞病理学在诊断口腔病变方面有效性的证据。我们对比较口腔病变细胞学和组织病理学诊断准确性的随机临床试验进行了系统的文献综述。我们使用了以下检索词：细胞学、口腔病变和口腔癌。根据系统评价和Meta分析的首选报告项目指南进行Meta分析。1967年至2010年间，文献中有80篇相关文章，其中14篇纳入本研究。敏感性的I方值为80.2%，特异性值为96.7%。合并敏感性为0.942[95%置信区间（CI）：0.926 - 0.955]，合并特异性为0.970（95%CI：0.963 - 0.975）。曲线下面积为0.9901。我们的研究表明，细胞学对口腔病变的诊断具有良好的敏感性和特异性，并允许使用其他相关技术，如DNA分析，这可能会提高细胞学的准确性。
