Morikawa M, Tokunaka S, Yachiku S, Yamauchi K, Wakabayashi A, Inagaki N, Nishihara M, Yamaguchi S
Department of Urology, Asahikawa Medical College.
Hinyokika Kiyo. 1990 Oct;36(10):1253-7.
The clinical efficacy of norfloxacin (NFLX) was evaluated on 40 patients. They had subjective symptoms suggestive of prostate inflammations and more than five white blood cells (WBC)/hpf in their prostatic secretions (EPS) or VB3. Of these, gram negative rods were isolated from the EPS in 3 patients and gram positive cocci were obtained in 26 patients. The overall clinical efficacy was determined at the second week. The effectiveness rate of the subjective symptoms was 82.5%. The effectiveness rate of the WBC in the EPS was 47.4%. The effectiveness rate of the bacteria in the EPS was 64.3%. The overall clinical effectiveness rate was 77.8%. A subjective side effect was observed only in one patient who had skin eruption like urticaria. Mild liver dysfunction of blood chemistry analysis was shown only in two patients but they had had long standing chronic hepatitis. We conclude that NFLX is an effective drug for the patients with chronic prostatitis.
对40例患者评估了诺氟沙星（NFLX）的临床疗效。这些患者有提示前列腺炎症的主观症状，且前列腺分泌物（EPS）或VB3中白细胞（WBC）每高倍视野超过5个。其中，3例患者的EPS中分离出革兰氏阴性杆菌，26例患者分离出革兰氏阳性球菌。在第二周确定总体临床疗效。主观症状有效率为82.5%。EPS中白细胞有效率为47.4%。EPS中细菌有效率为64.3%。总体临床有效率为77.8%。仅1例出现主观副作用，表现为荨麻疹样皮疹。仅2例患者血液化学分析显示轻度肝功能异常，但他们患有长期慢性肝炎。我们得出结论，NFLX对慢性前列腺炎患者是一种有效药物。
