Antropova I P, Iushkov B G
Ross Fiziol Zh Im I M Sechenova. 2012 Mar;98(3):424-32.
Effect of the initial state of the plasma hemostasis on the hemocoagulation changes after the total arthroplasty surgery was studied in 100 patients with osteoarthritis. Indicators of coagulation, fibrinolysis, and physiological anticoagulants were determined before and after completion of the surgery, at days 1, 3, 7, and 13-14 postoperatively. Increased coagulation activity befor surgery enhanced blood clotting within three days after the surgery. Enhanced consumption of physiological anticoagulants reduced the ability to recover their level a week after arthroplasty. The raised activity of the fibrinolysis inhibitor retained the effect during three postoperative days. Initial abnormalities in plasma hemostasis enhance blood coagulation dysfunction caused by surgical intervention on the large joints.
对100例骨关节炎患者研究了血浆止血初始状态对全关节置换术后血液凝固变化的影响。在手术完成前以及术后第1、3、7和13 - 14天测定凝血、纤维蛋白溶解和生理性抗凝剂指标。术前凝血活性增加会增强术后三天内的血液凝固。生理性抗凝剂消耗增加会降低关节置换术后一周恢复其水平的能力。纤维蛋白溶解抑制剂活性升高在术后三天内持续存在影响。血浆止血的初始异常会增强大关节手术干预引起的血液凝固功能障碍。
