Ivanova V P, Krivchenko A I
Zh Evol Biokhim Fiziol. 2012 Mar-Apr;48(2):118-28.
This review summarizes current data on structure of the most representative group of the collagen family--fibrillar collagens. Attention has been focused on structural organization of individual domains and their functional role in the hierarchical stacking of alpha-chains of collagens. There is presented characteristics of the main stages of biosynthesis and of supramolecular processing of fibrillar collagens. Also considered are some aspects of evolution of fibrillar collagens. The role of duplication of genome and genes, intergene rearrangements, and exon shuffling in evolution of collagen genes is discussed.
本综述总结了关于胶原蛋白家族中最具代表性的一组——纤维状胶原蛋白结构的当前数据。重点关注了各个结构域的结构组织及其在胶原蛋白α链分层堆积中的功能作用。文中介绍了纤维状胶原蛋白生物合成和超分子加工主要阶段的特征。还探讨了纤维状胶原蛋白进化的一些方面。讨论了基因组和基因复制、基因间重排以及外显子改组在胶原蛋白基因进化中的作用。