Bottoms G D, Fessler J F, Johnson M, Coatney R W, Voorhees W
Department of Veterinary Physiology, Purdue University, West Lafayette, Indiana 47907.
Alcohol Clin Exp Res. 1990 Oct;14(5):776-80. doi: 10.1111/j.1530-0277.1990.tb01245.x.
The specific aim of this research was to test the hypothesis that intoxication with alcohol results in poor tolerance to hemorrhage. This was evaluated on the basis of blood pressure, cardiac output respiratory rate, blood flow to organs, and survival for 4 hr after hemorrhage. Four groups of six swine per group were used (control, intoxicated, hemorrhage, and intoxicated-hemorrhage). The results revealed that blood alcohol concentrations near 0.1% greatly reduced tolerance to hemorrhage. Intoxicated animals subjected to hemorrhage were unable to maintain an adequate cardiac output, blood pressure, or respiratory rate to sustain life. Pigs tolerated higher blood alcohol concentrations, up to 0.35%, when not exposed to hemorrhage. Also, unintoxicated pigs were able to compensate for severe hemorrhage. Only one of the six pigs in the intoxicated-hemorrhage group survived for 4 hr after hemorrhage. In conclusion the body's ability to compensate and recover from hemorrhage was greatly reduced during intoxication. It is logical to assume that the ability to overcome numerous other stressors may also be reduced during intoxication.
本研究的具体目的是检验酒精中毒会导致出血耐受性差这一假设。这是根据血压、心输出量、呼吸频率、器官血流量以及出血后4小时的存活率来评估的。使用了四组，每组六头猪（对照组、中毒组、出血组和中毒出血组）。结果显示，血液酒精浓度接近0.1%会大大降低对出血的耐受性。遭受出血的中毒动物无法维持足够的心输出量、血压或呼吸频率来维持生命。在未遭受出血时，猪能耐受高达0.35%的更高血液酒精浓度。此外，未中毒的猪能够代偿严重出血。中毒出血组的六头猪中只有一头在出血后存活了4小时。总之，中毒期间身体从出血中代偿和恢复的能力大大降低。合乎逻辑的推测是，中毒期间克服众多其他应激源的能力也可能降低。
