Determination of the activity of nonspecific monophosphoesterases and nonspecific esterase in the liver of dogs in extrahepatic cholestasis treated surgically and with phenobarbital.

Histochemical researches on livers of 19 dogs were carried out. The dogs suffered from extrahepatic cholestasis which lasted for 28 days and was surgically induced. The dogs were divided into three groups, out of which two were given phenobarbital for 21 or 28 days. In all groups biliary obstruction was removed by surgical operation. It was shown that a combined surgical treatment with the application of phenobarbital has given better results than a surgical treatment alone.