疟原虫感染的遗传因素以及与寄生虫逃避相关的宿主免疫反应。

Genetic aspects of malaria parasite infection and the host immune response in relation to parasite evasion.

作者信息

Pereira da Silva L

机构信息

Unité de Parasitologie expérimentale, Institut Pasteur, Paris, France.

出版信息

Ann Parasitol Hum Comp. 1990;65 Suppl 1:15-7. doi: 10.1051/parasite/1990651015.

DOI:10.1051/parasite/1990651015

PMID:2264675

Abstract

In relation to problems found up to now for the development of vaccines against malaria, recent studies have pointed out the different strategies evolved by the parasites to evade the host immune response. They include antigenic variation, antigenic polymorphism, antigenic mimicry and direct interference with the generation of the host immune response. These different mechanisms are rapidly reviewed and discussed with the aim of focusing the actual orientation of basic and applied research which has been developed to overcome these difficulties.

摘要

关于迄今为止疟疾疫苗研发中发现的问题，近期研究指出了疟原虫为逃避宿主免疫反应而演化出的不同策略。这些策略包括抗原变异、抗原多态性、抗原模拟以及直接干扰宿主免疫反应的产生。本文对这些不同机制进行了快速回顾和讨论，旨在聚焦为克服这些困难而开展的基础研究和应用研究的实际方向。