Cardiology Department, University Hospital of Patras, Patras, Greece.
Platelets. 2013;24(3):239-41. doi: 10.3109/09537104.2012.682104. Epub 2012 May 30.
We describe a case of a 34-year-old woman with chronic renal failure under haemodialysis. The patient exhibited high on-treatment platelet reactivity to gradually stronger thienopyridine regimens, including standard and high maintenance doses of prasugrel. Platelet function was monitored by VerifyNow assay and genotyping for various single-nucleotide polymorphisms was performed. Treatment with ticagrelor 180 mg/day was effective in reducing the platelet reactivity.
我们描述了一例 34 岁女性慢性肾衰竭患者行血液透析，该患者对噻吩吡啶类药物（包括标准剂量和高维持剂量的普拉格雷）的治疗反应呈高血小板反应性，逐渐增强。通过 VerifyNow 检测法监测血小板功能，并对各种单核苷酸多态性进行基因分型。每天使用 180mg 替格瑞洛治疗可有效降低血小板反应性。
