Udén P, Tibblin S
Department of Surgery, Malmö General Hospital, University of Lund, Sweden.
Ann Chir Gynaecol. 1990;79(3):123-8.
In a multicentre study including 5 surgical departments in Europe and USA the results of surgical treatment in primary hyperparathyroidism (HPT) due to single adenoma were analysed. At long term follow-up 60 out of 282 patients operated on for solitary parathyroid adenoma were found to be dead. The average age at operation was 69.2 years and the time of survival after surgery 3.9 years. The cumulative relative survival in patients aged 60-64 years was reduced by 18% (P less than 0.01) as compared to a control group corrected for nationality, age and gender. In patients above the age of 65 no such reduction could be demonstrated. The operative mortality was 1% and attributed to cardiac failures. Late mortality was caused by cardiovascular conditions in 52% and by malignant disease in 15%. None of these figures were statistically different from the age, gender and nation corrected control group. Among the miscellaneous causes of death were two patients who committed suicide during the first postoperative year. The results indicate that surgery for parathyroid adenoma can be performed with low morbidity and mortality.
在一项涵盖欧洲和美国5个外科科室的多中心研究中，分析了因单发腺瘤导致的原发性甲状旁腺功能亢进症（HPT）的外科治疗结果。在对282例因孤立性甲状旁腺腺瘤接受手术的患者进行长期随访时，发现其中60例已死亡。手术时的平均年龄为69.2岁，术后生存时间为3.9年。与根据国籍、年龄和性别校正的对照组相比，60 - 64岁患者的累积相对生存率降低了18%（P < 0.01）。在65岁以上的患者中未发现此类降低情况。手术死亡率为1%，归因于心力衰竭。晚期死亡率由心血管疾病导致的占52%，由恶性疾病导致的占15%。这些数字与经年龄、性别和国籍校正的对照组相比均无统计学差异。在各种死因中，有两名患者在术后第一年自杀。结果表明，甲状旁腺腺瘤手术的发病率和死亡率较低。
