Bmp2 调节心脏 OFT 中 EPDCs 和心肌细胞之间的相互作用。

Bmp2 regulates the interaction between EPDCs and myocytes in cardiac OFT.

机构信息

Pediatric Heart Center, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, China.

出版信息

Med Hypotheses. 2012 Aug;79(2):174-7. doi: 10.1016/j.mehy.2012.04.027. Epub 2012 May 28.

DOI:10.1016/j.mehy.2012.04.027

Abstract

Epicardium-derived cells (EPDCs) can migrate into the myocardium, giving rise to several types of cell which are indispensable to compact myocardium and inducing normal myocardial development. Subepicardium accumulates bone morphogenetic proteins (Bmps), which can release into myocardium further. It has been shown that reduced Bmp-mediated signaling in a novel neural crest derivative in the epicardium reduced the cardiomyocyte proliferative activity in the developing myocardium. Furthermore, studies have demonstrated that cardiomyocytes can develop in proepicardial organ (PEO) explant cultures after stimulation with bone morphogenetic protein (Bmp2). We present a hypothesis that Bmp2 regulates the interaction between EPDCs and cardiomyocyte in the developing outflow tract (OFT). Our previous empirical data also shows that Bmp2 is expressed in the myocardial cell in the OFT at embryonic day (E) 14.5 in wild-type mice, and expression of Bmp2 in Cx43α1 knockout (KO) OFT was delayed for 1day. Further validation of this hypothesis will provide additional insight of the molecular mechanism of myocardium maturation.

摘要

心外膜衍生细胞（EPDCs）可以迁移到心肌中，产生几种类型的细胞，这些细胞对致密心肌的形成和诱导正常心肌发育是必不可少的。心外膜下区域积累骨形态发生蛋白（Bmps），这些蛋白可以进一步释放到心肌中。已经表明，心外膜中一种新型神经嵴衍生物中 Bmp 介导体信号的减少，降低了发育中心肌中心肌细胞的增殖活性。此外，研究表明，在骨形态发生蛋白（Bmp2）的刺激下，原心外胚层器官（PEO）外植体培养中的心肌细胞可以发育。我们提出一个假设，即 Bmp2 调节发育中的流出道（OFT）中 EPDCs 和心肌细胞之间的相互作用。我们之前的实验数据还表明，在野生型小鼠中，Bmp2 在胚胎第 14.5 天的 OFT 心肌细胞中表达，而 Cx43α1 敲除（KO）OFT 中的 Bmp2 表达延迟了 1 天。对这一假设的进一步验证将为心肌成熟的分子机制提供更多的见解。