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Autologous transplantation of RPE with partial-thickness choroid after mechanical debridement of Bruch membrane in the rabbit.兔Bruch膜机械清创后自体视网膜色素上皮细胞与部分厚度脉络膜移植术
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本文引用的文献

1
Stem cells and eye development.干细胞与眼部发育。
N Engl J Med. 2011 Jul 28;365(4):370-2. doi: 10.1056/NEJMcibr1105280.
2
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment.人多能干细胞诱导形成的类视囊泡结构有助于实现视网膜疾病治疗的个体化策略。
Stem Cells. 2011 Aug;29(8):1206-18. doi: 10.1002/stem.674.
3
Self-organizing optic-cup morphogenesis in three-dimensional culture.三维培养中的自组织视杯形态发生。
Nature. 2011 Apr 7;472(7341):51-6. doi: 10.1038/nature09941.
4
Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.从一名回旋性萎缩症患者诱导多能干细胞中进行基因矫正和分析。
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6537-42. doi: 10.1073/pnas.1103388108. Epub 2011 Apr 4.
5
Scaffolds for retinal pigment epithelium (RPE) replacement therapy.用于视网膜色素上皮（RPE）替代疗法的支架。
Br J Ophthalmol. 2011 Apr;95(4):441-2. doi: 10.1136/bjo.2009.171926.
6
Expanded polytetrafluoroethylene as a substrate for retinal pigment epithelial cell growth and transplantation in age-related macular degeneration.聚四氟乙烯作为视网膜色素上皮细胞生长和移植的基质在年龄相关性黄斑变性中的应用。
Br J Ophthalmol. 2011 Apr;95(4):569-73. doi: 10.1136/bjo.2009.169953. Epub 2011 Feb 11.
7
Robust cell integration from co-transplantation of biodegradable MMP2-PLGA microspheres with retinal progenitor cells.共移植可生物降解的 MMP2-PLGA 微球与视网膜祖细胞可实现细胞的稳定整合。
Biomaterials. 2011 Feb;32(4):1041-50. doi: 10.1016/j.biomaterials.2010.09.063. Epub 2010 Oct 28.
8
Biodegradable poly(α-hydroxy ester) blended microspheres as suitable carriers for retinal pigment epithelium cell transplantation.可生物降解的聚（α-羟基酯）共混微球作为视网膜色素上皮细胞移植的合适载体。
J Biomed Mater Res A. 2010 Dec 15;95(4):1233-43. doi: 10.1002/jbm.a.32940. Epub 2010 Oct 11.
9
Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells.使用流式分选的 Crx 阳性供体细胞在小儿视网膜病变莱伯先天性黑矇的模型中进行视锥和视杆光感受器移植。
Hum Mol Genet. 2010 Dec 1;19(23):4545-59. doi: 10.1093/hmg/ddq378. Epub 2010 Sep 21.
10
Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation.移植到成年鼠神经视网膜中的光感受器的长期存活需要免疫调节。
Stem Cells. 2010 Nov;28(11):1997-2007. doi: 10.1002/stem.520.

眼科移植学：眼部后节--第二部分。

Ophthalmic transplantology: posterior segment of the eye--part II.

机构信息

Domestic and Specialized Medicine Centre Dilmed, Katowice, Poland.

出版信息

Med Sci Monit. 2012 Jun;18(6):RA97-103. doi: 10.12659/msm.882868.

DOI:10.12659/msm.882868
PMID:22648265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3560715/
Abstract

BACKGROUND

Transplants of the retina are among the new strategies being used in the treatment of genetic and degenerative macular diseases. Moreover, various cell cultures are being tested to treat retinal disorders.

MATERIAL/METHODS: Literature dated from 2004 to 2011 was comprehensively examined via Medline and PubMed searches for the following terms: auto-, homo-, heterologous transplantation, retina, stem cells, cultivated cells.

RESULTS

Tissue and cell therapy of retinal diseases are reviewed, including full-thickness retina/retinal pigment epithelium (RPE)/choroid graft; full and partial thickness RPE/choroid complex grafts; RPE/Bruch membrane complex graft; and RPE, iris pigment epithelium and stem cell grafts. Recommendations for transplants, as well as the benefits and weaknesses of specific techniques in retina transplants, are discussed.

CONCLUSIONS

Auto- and allogenic transplants of a full or partial thickness retina/RPE/ Bruch membrane/choroid complex represent an alternative treatment offered to patients with some macular diseases. Stem cell transplantation to reconstruct and regenerate the macula requires further biomolecular and animal research studies.

摘要

背景

视网膜移植是治疗遗传性和退行性黄斑疾病的新策略之一。此外，正在测试各种细胞培养物来治疗视网膜疾病。

材料/方法：通过 Medline 和 PubMed 搜索以下术语，全面检查了 2004 年至 2011 年的文献：自身、同种、异源移植、视网膜、干细胞、培养细胞。

结果

综述了视网膜疾病的组织和细胞治疗，包括全厚视网膜/视网膜色素上皮（RPE）/脉络膜移植物；全厚和部分厚度 RPE/脉络膜复合物移植物；RPE/布鲁赫膜复合物移植物；RPE、虹膜色素上皮和干细胞移植物。讨论了移植的建议，以及特定视网膜移植技术的优缺点。

结论

全厚或部分厚度视网膜/RPE/布鲁赫膜/脉络膜复合物的自体和同种异体移植为某些黄斑疾病患者提供了替代治疗。干细胞移植以重建和再生黄斑需要进一步的生物分子和动物研究。