Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Mail Stop M4-B874, Seattle, WA 98109-1024, USA.
Breast Cancer Res Treat. 2012 Jul;134(2):801-9. doi: 10.1007/s10549-012-2099-0. Epub 2012 May 31.
African American (AA) women have a higher mortality from breast cancer (BC) compared to European American (EA) women. This may be due to the higher proportion of AA women with tumors that are diagnosed at more advanced stages and are characterized as being estrogen receptor negative (ER-)/progesterone receptor negative (PR-). Our study sought to determine whether self-reported race and percent African ancestry were associated with BC tumor characteristics. In a multi-center, population-based case-control study of BC, we determined percent African ancestry using ancestry informative markers (AIM) among women self-reporting race as AA or Black. BC tumor characteristics were associated with self-reported race (including a 30 % reduction in ER+/PR+ tumors [95 % confidence interval [CI]: 0.6-0.9] and a 1.5-fold increased risk of high grade [95 % CI: 1.2-1.9] for AA women compared to EA women). AIMs among AA women were not associated with BC tumor characteristics (AA women with ≥95 % versus <80 % African ancestry, odds ratio [OR] = 1.0 for ER+/PR+ [95 % CI: 0.6-1.8] and OR = 0.9 for high-grade tumors [95 % CI: 0.6-1.4]). Similar findings were observed for BC stage. While BC subtypes were associated with self-reported race, BC subtypes were not associated with percent African ancestry. These study results suggest that subtle differences in percent African ancestry are less important than the overall presence of African ancestry in relation to BC tumor characteristics.
非裔美国女性（AA）患乳腺癌（BC）的死亡率高于欧洲裔美国女性（EA）。这可能是由于 AA 女性中更多比例的肿瘤被诊断为更晚期，并且表现为雌激素受体阴性（ER-）/孕激素受体阴性（PR-）。我们的研究旨在确定自我报告的种族和非洲裔后裔百分比是否与 BC 肿瘤特征相关。在一项多中心、基于人群的 BC 病例对照研究中，我们使用在自我报告为 AA 或黑人的女性中报告的种族，使用种族信息标记物（AIM）确定非洲裔后裔百分比。BC 肿瘤特征与自我报告的种族相关（与 EA 女性相比，AA 女性的 ER+/PR+肿瘤减少 30%[95%置信区间：0.6-0.9]，高级别肿瘤的风险增加 1.5 倍[95%置信区间：1.2-1.9]）。AA 女性中的 AIM 与 BC 肿瘤特征无关（AA 女性中非洲裔后裔百分比≥95%与<80%，ER+/PR+肿瘤的比值比[OR]为 1.0[95%置信区间：0.6-1.8]，高级别肿瘤的 OR 为 0.9[95%置信区间：0.6-1.4]）。对于 BC 分期也观察到了类似的发现。虽然 BC 亚型与自我报告的种族相关，但 BC 亚型与非洲裔后裔百分比无关。这些研究结果表明，与 BC 肿瘤特征相关的非洲裔后裔百分比的细微差异不如总体存在非洲裔后裔重要。
