帕金森病冲动控制障碍患者眶额内侧皮质 [18F]氟多巴摄取增加。
Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disorders.
机构信息
Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland.
出版信息
Mov Disord. 2012 May;27(6):778-82. doi: 10.1002/mds.24941. Epub 2012 Feb 5.
BACKGROUND
Impulse control disorders (ICDs) occur frequently in PD patients.
METHODS
To investigate the possible involvement of the mesostriatal and mesolimbic monoaminergic function in ICDs associated with PD, we examined patients with (n = 10) and without (n = 10) ICDs using the brain [(18) F]fluorodopa PET.
RESULTS
Patients with ICDs (e.g., pathological gambling, hypersexuality, and compulsive eating) showed up to 35% higher [(18) F]fluorodopa uptake in the medial orbitofrontal cortex, compared to control patients, but no differences in the striatum. The results remained significant also after excluding subjects with comorbid psychiatric disorders.
CONCLUSIONS
Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine-replacement therapy in PD.
背景
冲动控制障碍（ICD）在 PD 患者中频繁发生。
方法
为了研究中脑-边缘单胺能功能在与 PD 相关的 ICD 中的可能作用，我们使用脑 [(18) F]氟多巴 PET 检查了 10 名患有 ICD（如病理性赌博、性欲亢进和强迫性进食）的患者和 10 名无 ICD 的患者。
结果
与对照组患者相比，患有 ICD 的患者（例如，病理性赌博、性欲亢进和强迫性进食）的内侧眶额皮质的 [(18) F]氟多巴摄取增加了高达 35%，但纹状体没有差异。在排除患有共病精神障碍的患者后，结果仍然显著。
结论
内侧眶额皮质中单胺能活性的增加可能与 PD 患者在多巴胺替代治疗下对 ICD 的敏感性增加有关。
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