Instituto de Tecnología Química UPV-CSIC, Universidad Politécnica de Valencia, Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos, s/n, 46022 Valencia, Spain.
Chemistry. 2012 Jun 25;18(26):8024-7. doi: 10.1002/chem.201201090. Epub 2012 May 30.
DNA damage: The reactivity of HO(.) with silylated 2'-deoxyribonucleosides was investigated in acetonitrile by means of a time-resolved technique. The obtained rate constants were in general slightly lower than those reported for the natural nucleosides in water. Analysis of the reaction mixture by UPLC-MS revealed that HO(.) attack occurred at the nucleobase (see scheme).
DNA 损伤：通过时间分辨技术在乙腈中研究了 HO(.)与硅烷化 2'-脱氧核苷的反应性。获得的速率常数通常略低于在水中报道的天然核苷的速率常数。通过 UPLC-MS 对反应混合物进行分析表明，HO(.)攻击发生在碱基上（见方案）。
