Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA.
J Clin Oncol. 2012 Sep 1;30(25):3127-35. doi: 10.1200/JCO.2011.37.0981. Epub 2012 May 29.
The B-cell lymphoma/leukemia 2 (BCL-2) family of proteins has attracted the attention of cancer biologists since the cloning of BCL-2 more than 25 years ago. In the intervening decades, the way the BCL-2 family controls commitment to programmed cell death has been greatly elucidated. Several drugs directed at inhibiting BCL-2 and related antiapoptotic proteins have been tested clinically, with some showing considerable promise, particularly in lymphoid malignancies. A better understanding of the BCL-2 family has also provided insight into how conventional chemotherapy selectively kills cancer cells and why some cancers are more chemosensitive than others. Further exploitation of our understanding of the BCL-2 family promises to offer improved predictive biomarkers for oncologists and improved therapies for patients with cancer.
B 细胞淋巴瘤/白血病 2(BCL-2)蛋白家族自 25 年前 BCL-2 被克隆以来,一直吸引着癌症生物学家的关注。在过去的几十年中,BCL-2 家族控制程序性细胞死亡的方式已经得到了充分的阐明。几种针对抑制 BCL-2 和相关抗凋亡蛋白的药物已在临床上进行了测试,其中一些显示出了相当大的前景,特别是在淋巴恶性肿瘤中。对 BCL-2 家族的更好理解也提供了深入了解常规化疗如何选择性地杀死癌细胞,以及为什么有些癌症比其他癌症更敏感于化疗的机制。进一步利用我们对 BCL-2 家族的理解,有望为肿瘤学家提供改进的预测生物标志物,并为癌症患者提供更好的治疗方法。