细胞中支架蛋白对钙激活氯通道的调节作用。

Institute of Cytology, Russian Academy of Sciences.

Acta Naturae. 2010 Jul;2(3):94-100.

Store-operated channels are major calcium influx pathways in nonexitable cells. Homer scaffold proteins are well known for their role in regulating calcium signaling. Here we report on a detailed single-channel level characterization of native store-operated channels regulated by Homer scaffold proteins in A431 carcinoma cells. By applying the single-channel patch-clamp technique, we found that different types of store-operated calcium channels have different sensitivities to Homer proteins.

储存操作通道是无兴奋性细胞中主要的钙离子内流途径。 Homer 支架蛋白以其在调节钙信号中的作用而闻名。在这里，我们报告了在 A431 癌细胞中 Homer 支架蛋白调节的天然储存操作通道的详细单通道水平特性。通过应用单通道膜片钳技术，我们发现不同类型的储存操作钙通道对 Homer 蛋白的敏感性不同。