默克尔细胞癌的组织学、免疫组织学及临床特征与默克尔细胞多瘤病毒状态的相关性
Histological, immunohistological, and clinical features of merkel cell carcinoma in correlation to merkel cell polyomavirus status.
作者信息
Jaeger T, Ring J, Andres C
机构信息
Department of Dermatology and Allergy Biederstein, Technische Universität München, 80802 Munich, Germany.
出版信息
J Skin Cancer. 2012;2012:983421. doi: 10.1155/2012/983421. Epub 2012 May 7.
Merkel cell carcinoma is a rare, but highly malignant tumor of the skin with high rates of metastasis and poor survival. Its incidence rate rises and is currently about 0.6/100000/year. Clinical differential diagnoses include basal cell carcinoma, cyst, amelanotic melanoma, lymphoma and atypical fibroxanthoma. In this review article clinical, histopathological and immunhistochemical features of Merkel cell carcinoma are reported. In addition, the role of Merkel cell polyomavirus is discussed.
默克尔细胞癌是一种罕见但高度恶性的皮肤肿瘤，转移率高且生存率低。其发病率呈上升趋势，目前约为每年0.6/100000。临床鉴别诊断包括基底细胞癌、囊肿、无色素性黑色素瘤、淋巴瘤和非典型纤维黄色瘤。在这篇综述文章中，报道了默克尔细胞癌的临床、组织病理学和免疫组织化学特征。此外，还讨论了默克尔细胞多瘤病毒的作用。
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