Department of Pathology, Yale University School of Medicine New Haven, CT, USA.
Front Oncol. 2012 Mar 12;2:26. doi: 10.3389/fonc.2012.00026. eCollection 2012.
Histone post-transcriptional modifications play essential roles in regulation of all DNA related processes. Among them, histone ubiquitination has been discovered for more than three decades. However, its functions are still less well understood than other histone modifications such as methylation and acetylation. In this review, we will summarize our current understanding of histone ubiquitination and deubiquitination. In particular, we will focus on how they are regulated by histone ubiquitin ligases and deubiquitinating enzymes. We will then discuss the roles of histone ubiquitination in transcription and DNA damage response and the crosstalk between histone ubiquitination and other histone modifications. Finally, we will review the important roles of histone ubiquitination in stem cell biology and cancer.
组蛋白转录后修饰在调节所有与 DNA 相关的过程中起着至关重要的作用。其中，组蛋白泛素化已经被发现了三十多年。然而，它的功能比其他组蛋白修饰（如甲基化和乙酰化）了解得更少。在这篇综述中，我们将总结我们目前对组蛋白泛素化和去泛素化的理解。特别是，我们将重点讨论它们是如何被组蛋白泛素连接酶和去泛素化酶调节的。然后，我们将讨论组蛋白泛素化在转录和 DNA 损伤反应中的作用，以及组蛋白泛素化与其他组蛋白修饰之间的相互作用。最后，我们将回顾组蛋白泛素化在干细胞生物学和癌症中的重要作用。
