Ura K, Hironaka Y, Sakurai I
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
Am J Cardiovasc Pathol. 1990;3(2):131-42.
To elucidate 1-carnitine chloride effects ischemic myocardium for the possibility of a salvage of risk zone around necrosis in myocardial infarcts of dogs, a quantitative evaluation of the extent of myocardial infarcts was done by size detection with use of monastral blue and tissue dehydrogenase histochemistry at 20 hours after coronary ligation. The results show that the ratio of unsalvaged infarct zone to occluded coronary bed is 85.3 +/- 2.9% in the control group, while it is 53.2 +/- 3.6% in the 1-carnitine administered (1 C) group. The difference between these ratios is statistically significant (p less than 0.01). The results also indicate significantly lower serum CPK concentration. Therefore, carnitine may play a role in preventing a size extention of infarcts through improving an altered lipid metabolism, particularly a fatty acid metabolism, of myocardial cells in the risk zone.
为了阐明氯化左旋肉碱对缺血心肌的作用，以及其挽救犬心肌梗死坏死周围危险区的可能性，在冠状动脉结扎20小时后，通过使用天青石蓝进行大小检测和组织脱氢酶组织化学方法，对心肌梗死范围进行了定量评估。结果显示，对照组中未挽救的梗死区与闭塞冠状动脉床的比例为85.3±2.9%，而在给予左旋肉碱（1-C）的组中该比例为53.2±3.6%。这些比例之间的差异具有统计学意义（p<0.01）。结果还表明血清肌酸磷酸激酶浓度显著降低。因此，肉碱可能通过改善危险区心肌细胞脂质代谢改变，尤其是脂肪酸代谢，在预防梗死面积扩大方面发挥作用。
