Masieri Lorenzo, Lanciotti Michele, Gontero Paolo, Marchioro Giansilvio, Mantella Annalisa, Zaramella Stefano, Minervini Andrea, Lapini Alberto, Carini Marco, Serni Sergio
Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.
Arch Ital Urol Androl. 2012 Mar;84(1):17-21.
The aim was to analyze the prognostic role of preoperative chromogranin A CgA) as a marker of poor prognosis and recurrence after radical prostatectomy (RP) and to find a correlation with the other well known prognostic variables.
This study comprises 306 patients with prostate cancer prospectively recruited who underwent RP from between 2000 and 2005. A blood sample for the determination of serum preoperative CgA value was obtained in all cases. Spearman correlation test was used to compare CgA to other variables, Kruskal-Wallis test to analyze CgA differences among > or = 3 groups (PSA, GS, Stage), Mann-Whitney test for 2 grouping variables. Survival analysis was estimated by Kaplan-Meier method, log-rank test to estimate differences among the analyzed variables.
Median CgA level was 68 ng/ml. Correlation between age and CgA levels was positive and statistically significant (p < 0.001). Patient were divided in 2 groups based on median age.The difference was statistically significant (p = 0.002). Comparison of CgA among patients grouped according to other variables and patient stratified on normal (123 ng/ml) and cut-off value (68 ng/ml) of CgA did not achieve significant risk stratification.
Studies on a possible prognostic role of CgA have provided conflicting results. In our series we found a significant positive correlation between CgA and age, but no significant statistical correlation with other available variables analyzed.
旨在分析术前嗜铬粒蛋白A（CgA）作为前列腺癌根治术（RP）后预后不良及复发标志物的预后作用，并找出其与其他已知预后变量的相关性。
本研究前瞻性纳入了2000年至2005年间接受RP的306例前列腺癌患者。所有病例均采集血样以测定术前血清CgA值。采用Spearman相关检验比较CgA与其他变量，采用Kruskal-Wallis检验分析CgA在≥3组（PSA、GS、分期）之间的差异，采用Mann-Whitney检验分析两个分组变量。采用Kaplan-Meier法进行生存分析，采用对数秩检验估计分析变量之间的差异。
CgA水平中位数为68 ng/ml。年龄与CgA水平呈正相关且具有统计学意义（p<0.001）。根据年龄中位数将患者分为两组，差异具有统计学意义（p = 0.002）。根据其他变量分组的患者以及根据CgA正常（123 ng/ml）和临界值（68 ng/ml）分层的患者中CgA的比较未实现显著的风险分层。
关于CgA可能的预后作用的研究结果相互矛盾。在我们的系列研究中，我们发现CgA与年龄之间存在显著正相关，但与分析的其他可用变量无显著统计学相关性。
