Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
J Intern Med. 2012 Dec;272(6):562-72. doi: 10.1111/j.1365-2796.2012.02562.x. Epub 2012 Jul 27.
We investigated serum concentrations of lipoprotein subclass particles and their lipid components determined by proton nuclear magnetic resonance spectroscopy in a population-based study.
A total of 9399 Finnish men were included in the study: 3034 men with normal fasting glucose and normal glucose tolerance; 4345 with isolated impaired fasting glucose (IFG); 312 with isolated impaired glucose tolerance (IGT); 1058 with both IFG and IGT; and 650 with newly diagnosed type 2 diabetes (New DM). Lipoprotein subclasses included chylomicrons (CM) and largest VLDL particles, other VLDL particles (five subclasses), intermediate-density lipoprotein (IDL), LDL (three subclasses) and HDL (four subclasses). The phospholipid, triglyceride (TG), cholesterol, free cholesterol and cholesterol ester levels of the lipoprotein particles were measured.
Abnormal glucose tolerance (especially IGT and New DM) was significantly associated with increased concentrations of VLDL subclass particles and their components (with the exception of very small VLDL particles). After further adjustment for total TGs and HDL cholesterol, increased lipid concentrations in the CM/largest VLDL particles and in most of the other VLDL particles remained significant in individuals with isolated IGT, IFG+IGT and New DM. There was a consistent trend towards a decrease in large and an increase in small HDL particle concentrations in individuals with hyperglycaemia even after adjustment for serum total TGs and HDL cholesterol.
Abnormal glucose tolerance modifies the concentrations of lipoprotein subclass particles and their lipid components in the circulation and is also related to compositional changes in these particles.
我们通过质子磁共振波谱法对人群进行研究，调查脂蛋白亚类颗粒及其脂质成分的血清浓度。
本研究共纳入 9399 名芬兰男性：3034 名空腹血糖正常和糖耐量正常的男性；4345 名单纯空腹血糖受损（IFG）男性；312 名单纯糖耐量受损（IGT）男性；1058 名 IFG 和 IGT 并存的男性；650 名新诊断的 2 型糖尿病（New DM）男性。脂蛋白亚类包括乳糜微粒（CM）和最大 VLDL 颗粒、其他 VLDL 颗粒（5 个亚类）、中间密度脂蛋白（IDL）、低密度脂蛋白（3 个亚类）和高密度脂蛋白（4 个亚类）。测量脂蛋白颗粒的磷脂、甘油三酯（TG）、胆固醇、游离胆固醇和胆固醇酯水平。
异常葡萄糖耐量（尤其是 IGT 和 New DM）与 VLDL 亚类颗粒及其成分浓度增加显著相关（除了非常小的 VLDL 颗粒外）。在进一步调整总 TG 和 HDL 胆固醇后，在单纯 IGT、IFG+IGT 和 New DM 个体中，CM/最大 VLDL 颗粒和大多数其他 VLDL 颗粒中的脂质浓度升高仍然显著。即使在调整血清总 TG 和 HDL 胆固醇后，高血糖个体的大 HDL 颗粒浓度呈下降趋势，小 HDL 颗粒浓度呈上升趋势。
异常葡萄糖耐量改变了循环中脂蛋白亚类颗粒及其脂质成分的浓度，并且还与这些颗粒的组成变化有关。
