Department of Pediatrics, Wayne State University School of Medicine, PET Center, Children's Hospital of Michigan, Detroit, MI 48201, USA.
Expert Rev Neurother. 2012 Jun;12(6):719-32. doi: 10.1586/ern.12.48.
Clinical positron emission tomography (PET) imaging of human epilepsy has a 30-year history, but it is still searching for its exact role among rapidly advancing neuroimaging techniques. The vast majority of epilepsy PET studies used this technique to improve detection of epileptic foci for surgical resection. Here, we review the main trends emerging from three decades of PET research in epilepsy, with a particular emphasis on how PET imaging has impacted on the clinical management of patients with intractable epilepsy. While reviewing the latest studies, we also present an argument for a changing role of PET and molecular imaging in the future, with an increasing focus on epileptogenesis and newly discovered molecular mechanisms of epilepsy. These new applications will be facilitated by technological advances, such as the use of integrated PET/MRI systems and utilization of novel radiotracers, which may also enhance phenotype-genotype correlations and assist rational, individualized treatment strategies.
临床正电子发射断层扫描（PET）成像在癫痫中的应用已有 30 年的历史，但在快速发展的神经影像学技术中，它仍在寻找其确切的作用。绝大多数癫痫 PET 研究都使用该技术来提高对手术切除的癫痫灶的检测。在这里，我们回顾了癫痫 PET 研究 30 年来出现的主要趋势，特别强调了 PET 成像如何影响耐药性癫痫患者的临床管理。在回顾最新研究的同时，我们还提出了一个论点，即 PET 和分子成像在未来的作用正在发生变化，越来越关注癫痫发生和新发现的癫痫分子机制。这些新的应用将得益于技术的进步，例如使用集成的 PET/MRI 系统和利用新型放射性示踪剂，这也可能增强表型-基因型相关性，并有助于合理的个体化治疗策略。
