Department of Chemistry & Biochemistry, University of Arizona, 1306 E. University Boulevard, Tucson, AZ 85721, USA.
Future Med Chem. 2012 May;4(8):951-4. doi: 10.4155/fmc.12.30.
Majority of pharmaceuticals are small molecule organic compounds. Their structures are most effectively described and communicated using the graphical language of organic chemistry. A few years ago we decided to harness this powerful language to create new educational tools that could serve well for data mining and as catalysts for discovery. The results were the Top 200 drug posters, which we have posted online for everyone to enjoy and update yearly. This article details the origin and motivation for our design and highlights the value of this graphical format by presenting and analyzing a new pharmaceutical structure montage (poster) focused on US FDA approved drugs in 2011.
大多数药物都是小分子有机化合物。它们的结构最有效地使用有机化学的图形语言来描述和交流。几年前，我们决定利用这种强大的语言来创建新的教育工具，这些工具可以很好地用于数据挖掘，并成为发现的催化剂。结果是前 200 名药物海报，我们已经将其在线发布，供大家欣赏，并每年更新。本文详细介绍了我们设计的起源和动机，并通过展示和分析一个新的关注 2011 年美国 FDA 批准药物的药物结构蒙太奇（海报），突出了这种图形格式的价值。
