Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, Rumelifeneri Yolu, Sariyer Istanbul, Turkey.
Curr Pharm Des. 2012;18(30):4697-705. doi: 10.2174/138161212802651643.
The growing perception that diseases are often consequences of multiple molecular abnormalities rather than being the result of a single defect highlights the importance of network-centric view in therapeutic approaches. Protein interaction networks may contribute to understanding of disease, assist in drug design and discovery. Here, we review some recent advances in disease-associated protein interaction networks taking a structural approach. We first describe structural aspects of protein-protein interactions and properties of protein interfaces as related to drug design; we address protein interactions in a network perspective; in particular, we illustrate how integrating protein interfaces onto interaction networks can guide the identification of selective drug targets or drugs targeting multiple proteins in a network.
人们越来越认识到，疾病往往是多种分子异常的结果，而不是单个缺陷的结果，这凸显了网络中心观点在治疗方法中的重要性。蛋白质相互作用网络有助于理解疾病，辅助药物设计和发现。在这里，我们从结构的角度综述了一些与疾病相关的蛋白质相互作用网络的最新进展。我们首先描述了蛋白质-蛋白质相互作用的结构方面和与药物设计相关的蛋白质界面特性；我们从网络的角度来探讨蛋白质相互作用；具体来说，我们说明了如何将蛋白质界面整合到相互作用网络中，可以指导选择性药物靶点或针对网络中多个蛋白质的药物的识别。
