School of Chemistry, University of Hyderabad, Hyderabad 500 046, A. P., India.
J Org Chem. 2012 Jun 15;77(12):5345-56. doi: 10.1021/jo300705f. Epub 2012 Jun 6.
Utilizing internally available functional groups, a simple protocol for the efficient synthesis of phosphorus-based indenes, indenones, benzofurans, and isochromenes via intramolecular cyclization of allene intermediates/precursors is generated; the latter intermediates/precursors are conveniently obtained through aldehyde-, alkylidene-, and hydroxyl-functionalized propargyl alcohols and P(III)-Cl precursors. The structures of key products have been unequivocally confirmed by X-ray crystallography.
利用内部可用的官能团，通过烯丙基中间体/前体的分子内环化，生成了一种用于高效合成磷基茚、茚酮、苯并呋喃和异色烯的简单方法；这些中间产物/前体可以通过醛基、亚烷基和羟基官能化的丙炔醇和 P(III)-Cl 前体制得。关键产物的结构已通过 X 射线晶体学得到明确证实。
