College of Chemistry and Chemical Engineering, Liaoning Normal University, 850 Huanghe Road, Dalian 116029, PR China.
Biosens Bioelectron. 2012 Oct-Dec;38(1):27-30. doi: 10.1016/j.bios.2012.04.036. Epub 2012 May 3.
Diglycolic acid (DA) polymer was coated on glassy carbon (GC) electrode by cyclic voltammetry (CV) technique for the first time. The electrochemical performances of the modified electrode were investigated by CV and electrochemical impedance (EIS). The obtained electrode showed an excellent electrocatalytic activity for the oxidation of acetaminophen (ACOP). A couple of well-defined reversible electrochemical redox peaks were observed on the ploy(DA)/GC electrode in ACOP solution. Compared with bare GC electrode, the oxidation peak potential of ACOP on ploy(DA)/GC electrode moved from 0.289 V to 0.220 V. Meanwhile, the oxidation peak current was much higher on the modified electrode than that on the bare GC electrode, indicating DA polymer modified electrode possessed excellent performance for the oxidation of ACOP. This kind of capability of the modified electrode can be enlisted for the highly sensitive and selective determination of ACOP. Under the optimized conditions, a wide linear range from 2 × 10(-8) to 5.0 × 10(-4)M with a correlation coefficient 0.9995 was obtained. The detection limit was 6.7 × 10(-9)M (at the ratio of signal to noise, S/N=3:1). The modified electrode also exhibited very good stability and reproducibility for the detection of ACOP. The established method was applied to the determination of ACOP in samples. An average recovery of 100.1% was achieved. These results indicated that this method was reliable for determining ACOP.
双甘醇酸 (DA) 聚合物首次通过循环伏安法 (CV) 技术涂覆在玻碳电极上。通过 CV 和电化学阻抗 (EIS) 研究了修饰电极的电化学性能。所得电极对醋氨酚 (ACOP) 的氧化表现出优异的电催化活性。在 ACOP 溶液中，在聚 (DA)/GC 电极上观察到一对定义良好的可逆电化学氧化还原峰。与裸 GC 电极相比，ACOP 在聚 (DA)/GC 电极上的氧化峰电位从 0.289 V 移动到 0.220 V。同时，修饰电极上的氧化峰电流远高于裸 GC 电极，表明 DA 聚合物修饰电极对 ACOP 的氧化具有优异的性能。这种修饰电极的能力可用于 ACOP 的高灵敏度和选择性测定。在优化条件下，从 2×10(-8)到 5.0×10(-4)M 获得了宽线性范围，相关系数为 0.9995。检测限为 6.7×10(-9)M（信噪比，S/N=3:1）。修饰电极还表现出非常好的稳定性和重现性，用于检测 ACOP。该方法已用于样品中 ACOP 的测定。平均回收率为 100.1%。这些结果表明该方法可靠，可用于测定 ACOP。
