Zonal distribution of peroxisomal 3-oxoacyl-CoA thiolase mRNA in liver from rats treated with di-(2-ethylhexyl)phthalate.
作者信息
Bout A, de Boer P A, Tager J M, Benne R, Moorman A F
机构信息
E.C. Slater Institute for Biochemical Research, University of Amsterdam, The Netherlands.
出版信息
Biochim Biophys Acta. 1990 Dec 10;1055(3):240-2. doi: 10.1016/0167-4889(90)90039-g.
PMID:2265212
Abstract
Treatment of rats with di-(2-ethylhexyl)phthalate leads to a dramatic increase in peroxisomal 3-oxoacyl-CoA thiolase RNA, the concentration being higher in the pericentral than in periportal hepatocytes. These findings indicate that the production of peroxisomal thiolase and the zonal distribution of the enzyme are regulated at a pretranslational level.
摘要
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