Hu O Y, Tang H S, Sheeng T Y, Chen S C, Lee S K, Chung P H
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Biopharm Drug Dispos. 1990 Oct;11(7):557-68. doi: 10.1002/bdd.2510110702.
Concentrations of promazine in plasma, plasma water, red blood cells, and urine were measured after oral administration of the drug to six patients during and after apparent recovery from the acute phase of viral hepatitis B. None of the promazine pharmacokinetic parameters were significantly different during and after the acute phase; these parameters included clearance, free drug clearance, metabolic clearance, volume of distribution, distribution and elimination half-life values, plasma protein binding, and per cent excreted in the urine. During the acute period of the illness, SGOP, SGPT, alkaline phosphatase, and total bilirubin were increased in all patients; they returned to within or near the upper limits or normal after recovery. Despite the unchanged promazine disposition, four out of six patients had more severe promazine side-effects, such as sedation, postural hypotension, and dizziness during the acute phase of the illness. This study suggests that promazine disposition was not significantly altered as a consequence of viral hepatitis. However, the pharmacodynamic effects of promazine were changed significantly. Care must be taken with patients who are taking promazine during the acute phase of viral hepatitis B.
在六名乙型病毒性肝炎急性期明显康复期间及之后口服异丙嗪后，测量了血浆、血浆水、红细胞和尿液中异丙嗪的浓度。在急性期期间和之后，异丙嗪的任何药代动力学参数均无显著差异；这些参数包括清除率、游离药物清除率、代谢清除率、分布容积、分布和消除半衰期值、血浆蛋白结合率以及尿中排泄百分比。在疾病急性期，所有患者的谷草转氨酶、谷丙转氨酶、碱性磷酸酶和总胆红素均升高；康复后恢复到正常上限或接近正常上限。尽管异丙嗪的处置情况未变，但六名患者中有四名在疾病急性期出现了更严重的异丙嗪副作用，如镇静、体位性低血压和头晕。本研究表明，异丙嗪的处置并未因病毒性肝炎而发生显著改变。然而，异丙嗪的药效学作用发生了显著变化。对于在乙型病毒性肝炎急性期服用异丙嗪的患者必须谨慎。
