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Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway.

作者信息

Xu S, Evans H, Buckle C, De Veirman K, Hu J, Xu D, Menu E, De Becker A, Vande Broek I, Leleu X, Camp B V, Croucher P, Vanderkerken K, Van Riet I

出版信息

Leukemia. 2012 Dec;26(12):2546-9. doi: 10.1038/leu.2012.126. Epub 2012 May 8.

DOI:10.1038/leu.2012.126
PMID:22652628
Abstract
摘要

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Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway.多发性骨髓瘤患者来源的间充质干细胞成骨分化受损与Notch信号通路失活受阻有关。
Leukemia. 2012 Dec;26(12):2546-9. doi: 10.1038/leu.2012.126. Epub 2012 May 8.
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Carfilzomib promotes the osteogenic differentiation potential of mesenchymal stem cells derived from myeloma patients by inhibiting notch1 activity in vitro.卡非佐米通过抑制骨髓瘤患者来源的间充质干细胞中的 notch1 活性，促进其成骨分化潜能。
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