Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Front Biosci (Landmark Ed). 2012 Jun 1;17(6):2070-88. doi: 10.2741/4038.
Superfamily 2 helicases are involved in all aspects of RNA metabolism, and many steps in DNA metabolism. This review focuses on the basic mechanistic, structural and biological properties of each of the families of helicases within superfamily 2. There are ten separate families of helicases within superfamily 2, each playing specific roles in nucleic acid metabolism. The mechanisms of action are diverse, as well as the effect on the nucleic acid. Some families translocate on single-stranded nucleic acid and unwind duplexes, some unwind double-stranded nucleic acids without translocation, and some translocate on double-stranded or single-stranded nucleic acids without unwinding.
超家族 2 解旋酶参与 RNA 代谢和 DNA 代谢的各个方面。这篇综述重点介绍了超家族 2 中每个解旋酶家族的基本机制、结构和生物学特性。超家族 2 中有十个独立的解旋酶家族，每个家族在核酸代谢中都发挥着特定的作用。作用机制多种多样，对核酸的影响也各不相同。有些家族在单链核酸上移位并解双链，有些家族在不发生移位的情况下解开双链核酸，有些家族在双链或单链核酸上移位而不解链。
