Sadegh-Nasseri Scheherazade, Chou Chih-Ling, Hartman Isamu Z, Kim AeRyon, Narayan Kedar
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Front Biosci (Schol Ed). 2012 Jun 1;4(4):1325-32. doi: 10.2741/s334.
Helper T cells respond to peptide antigens derived from exogenous sources presented by MHC II on antigen presenting cells. Antigens from pathogens are internalized by professional antigen presenting cells (APC) and processed for presentation. Certain epitopes are selected during processing as the final peptides for stimulation of T cells and are termed "immunodominant". Understanding how selection of immunodominant epitopes takes place has been a difficult task because of the complexity of the mechanisms governing both antigen processing and T cell recognition. In this review, we discuss our current understanding of HLA-DM function in peptide exchange and selection and its relevance to epitope immunodominance.
辅助性T细胞对由抗原呈递细胞上的MHC II呈现的外源性来源的肽抗原作出反应。病原体的抗原被专职抗原呈递细胞（APC）内化并进行加工以用于呈递。在加工过程中会选择某些表位作为刺激T细胞的最终肽，这些肽被称为“免疫显性”。由于控制抗原加工和T细胞识别的机制很复杂，了解免疫显性表位的选择过程一直是一项艰巨的任务。在这篇综述中，我们讨论了我们目前对HLA-DM在肽交换和选择中的功能及其与表位免疫显性的相关性的理解。
