Department of Dermatology, University of California, Irvine, Irvine, CA, USA.
Dermatitis. 2011 Sep-Oct;22(5):272-6. doi: 10.2310/6620.2011.11065.
The systemic toxicity of phthalates has been extensively reported. Although rarely sensitizing, phthalates have been implicated in promoting the development of both atopy and contact dermatitis in animal models. Dermal absorption of phthalates may contribute to overall chemical burden. Infants may be particularly susceptible to chemical exposures. Baby skin care products may be a significant source of phthalate exposure.
We measured the phthalate content of 30 skin care products intended for babies and children.
Nineteen leave-on and 11 wash-off baby skin care products were analyzed for 17 unique phthalates by an independent laboratory using standard gas chromatographic mass spectrometry.
Of 30 products tested, four had phthalate levels above the reporting limit (0.1-0.5 ppm); of these, only one had levels above 1 ppm (44 ppm). There was no statistical significance of phthalate detection in leave-on versus wash-off products (p = .578).
The majority (26 of 30) of the baby skin care products analyzed did not have detectable phthalate levels. Four products had detectable phthalate levels. In baby skin care products, levels of the 17 phthalates tested are low overall, but occasional products may contain higher phthalate levels. Monitoring products to ensure safety standards are met may be warranted.
邻苯二甲酸酯的全身毒性已被广泛报道。尽管邻苯二甲酸酯很少引起致敏,但它们已被认为会促进动物模型中特应性皮炎和接触性皮炎的发展。邻苯二甲酸酯的皮肤吸收可能会导致整体化学物质负担增加。婴儿可能特别容易受到化学物质暴露的影响。婴儿护肤品可能是邻苯二甲酸酯暴露的一个重要来源。
我们测量了 30 种婴儿和儿童用护肤品中的邻苯二甲酸酯含量。
由独立实验室使用标准气相色谱-质谱法对 19 种外用和 11 种水洗婴儿护肤品进行了 17 种独特邻苯二甲酸酯的分析。
在 30 种测试产品中,有 4 种产品的邻苯二甲酸酯含量超过报告限值(0.1-0.5 ppm);其中只有 1 种产品的含量超过 1 ppm(44 ppm)。外用产品与水洗产品的邻苯二甲酸酯检出率无统计学意义(p =.578)。
在分析的 30 种婴儿护肤品中,大多数(26 种)未检出邻苯二甲酸酯。有 4 种产品检测到邻苯二甲酸酯。在婴儿护肤品中,所测试的 17 种邻苯二甲酸酯的含量总体较低,但偶尔也会有产品含有较高的邻苯二甲酸酯。有必要对产品进行监测,以确保符合安全标准。