a College of Graduate Sciences , Gulf Medical University , Ajman , UAE.
b College of Pharmacy , Gulf Medical University , Ajman , UAE.
Toxicol Mech Methods. 2019 Jan;29(1):60-66. doi: 10.1080/15376516.2018.1512179. Epub 2018 Sep 26.
Phthalates are used as plasticizers in a wide range of products and are known to affect the human health adversely. Hence, the present study was carried out to identify and quantify the presence of four phthalates namely dimethyl phthalate (DMP), dibutyl phthalate (DBP), and diethyl phthalate (DEP), di (2-ethylhexyl) phthalate (DEHP) in the two baby products i.e. baby oils and baby lotions. The daily exposure levels and hazard index of each phthalate were also calculated. It was an analytical study where two different brands of samples of baby oil and baby lotion each, from the date of manufacturing of 3, 10, and 20 months were collected. The extraction of phthalates from different samples was done and analyzed using HPTLC. Results showed the presence of all four phthalates, although some phthalates were not present in 3 M samples. The maximum concentration of all the phthalates was found in 20 M samples. Their concentration increased with the storage time indicating the possibility of leaching and migration of phthalates from the container into the product. The hazard indices for phthalates estimated for baby oil and baby lotion were found below 1, which denotes that the daily phthalate exposures are within the regulatory limits. It is important to consider that the exposure to phthalates can occur not only by dermal contact of these baby products but also through other routes. Hence, the study signifies the importance of phthalates concentration in such regularly used products.
邻苯二甲酸酯被广泛用于各种产品中作为增塑剂，已知会对人体健康产生不利影响。因此，本研究旨在鉴定和量化两种婴儿产品（即婴儿油和婴儿乳液）中存在的四种邻苯二甲酸酯，即邻苯二甲酸二甲酯（DMP）、邻苯二甲酸二丁酯（DBP）、邻苯二甲酸二乙酯（DEP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）。还计算了每种邻苯二甲酸酯的日暴露水平和危害指数。这是一项分析性研究，收集了两种不同品牌的婴儿油和婴儿乳液样本，每个品牌分别有 3、10 和 20 个月生产日期的样本。使用 HPTLC 从不同样本中提取和分析邻苯二甲酸酯。结果表明所有四种邻苯二甲酸酯都存在，尽管有些邻苯二甲酸酯在 3 个月的样本中不存在。所有邻苯二甲酸酯的最大浓度都出现在 20 个月的样本中。它们的浓度随着储存时间的增加而增加，表明邻苯二甲酸酯有可能从容器中浸出和迁移到产品中。估计婴儿油和婴儿乳液中邻苯二甲酸酯的危害指数低于 1，这表示每日邻苯二甲酸酯暴露量在监管范围内。需要考虑的是，不仅通过这些婴儿产品的皮肤接触，而且还通过其他途径，可能会接触到邻苯二甲酸酯。因此，该研究强调了定期使用的产品中邻苯二甲酸酯浓度的重要性。
