Department of Dermatology, University of Modena, Modena, Italy.
Dermatology. 2012;224(3):262-70. doi: 10.1159/000338696. Epub 2012 May 25.
Melanomas in situ (MIS) are difficult to diagnose, lacking well-established dermoscopic descriptors.
The aim of this study was to improve the identification of early melanomas describing the variegated dermoscopic features of MIS and their correlation with demographic and clinical aspects.
Dermoscopic images of 114 histologically proven MIS were evaluated by 3 expert dermoscopists and classified into their main dermoscopic patterns. Dermoscopic features were also considered for their correlation with clinical parameters.
Eight different dermoscopic subtypes of MIS were identified: reticular grey-blue (27.2%), reticular (21.1%), multicomponent (20.2%), island (10.5%), spitzoid (7%), inverse network (6.1%), 'net-blue globules' (5.3%) and globular (2.6%). Clinical characteristics of lesions and patients varied according to the different dermoscopic groups.
We hypothesize that the different dermoscopic subgroups of MIS correspond to lesions with a different origin and, possibly, various patterns of growth and a different biological behaviour.
原位黑色素瘤（MIS）难以诊断，缺乏成熟的皮肤镜描述。
本研究旨在通过描述 MIS 的斑驳皮肤镜特征及其与人口统计学和临床方面的相关性，提高早期黑色素瘤的识别能力。
由 3 名专家皮肤镜医生评估 114 例组织学证实的 MIS 的皮肤镜图像，并将其分类为主要皮肤镜模式。还考虑了皮肤镜特征与临床参数的相关性。
确定了 8 种不同的 MIS 皮肤镜亚型：网状灰蓝色（27.2%）、网状（21.1%）、多组分（20.2%）、岛状（10.5%）、棘皮瘤样（7%）、逆网络（6.1%）、“网蓝球”（5.3%）和球状（2.6%）。病变和患者的临床特征根据不同的皮肤镜组而有所不同。
我们假设 MIS 的不同皮肤镜亚组对应于起源不同的病变，并且可能具有不同的生长模式和不同的生物学行为。
