维拉帕米对米托蒽醌和阿霉素体外抗肾癌细胞作用的影响。

The effect of verapamil on the anti-tumour action of mitozantrone and doxorubicin against renal carcinoma cells in vitro.

作者信息

Lai T, Morgan A P, Smith P J, Symes M O

机构信息

Department of Surgery, Royal Infirmary, Bristol.

出版信息

Br J Urol. 1990 Dec;66(6):596-601. doi: 10.1111/j.1464-410x.1990.tb07189.x.

DOI:10.1111/j.1464-410x.1990.tb07189.x

PMID:2265330

Abstract

Ten renal carcinomas were established in culture and their sensitivity to mitozantrone +/- verapamil, as measured by (75Se) selenomethionine incorporation, was studied. The 5 tumours with spread beyond the kidney were those in which sensitivity to mitozantrone was enhanced by verapamil. With 4 of the 10 tumours and 1 further carcinoma, similar experiments were performed using doxorubicin. This drug was more active, its anti-tumour action being related to concentration. Verapamil was more effective in potentiation of doxorubicin and this action increased in proportion to the concentration of verapamil added.

摘要

培养了10个肾癌细胞株，通过（75Se）硒代蛋氨酸掺入法研究了它们对米托蒽醌±维拉帕米的敏感性。5个已扩散至肾脏以外的肿瘤，维拉帕米增强了其对米托蒽醌的敏感性。对10个肿瘤中的4个以及另外1个癌进行了类似实验，使用阿霉素。这种药物活性更强，其抗肿瘤作用与浓度相关。维拉帕米对阿霉素的增效作用更有效，且这种作用随添加的维拉帕米浓度成比例增加。