Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Owada-shinden, Yachiyo, Chiba, Japan.
Retina. 2012 Oct;32(9):1844-52. doi: 10.1097/IAE.0b013e318259569f.
To evaluate the changes of macular sensitivity, thickness, and total macular volume after intravitreal injection of triamcinolone acetonide to treat macular edema with branch retinal vein occlusion.
Seventeen eyes of 17 patients with branch retinal vein occlusion with macular edema received intravitreal triamcinolone acetonide. Using capillary nonperfusion on fluorescein angiography, patients were classified into nonischemic or ischemic groups. Microperimetry was used to measure macular sensitivity within the central 4°, 10°, and 20° fields. Macular thickness and macular volume within these fields were measured by optical coherence tomography.
The mean macular thickness within the central 4°, 10°, and 20° fields decreased significantly after intravitreal therapy (all Ps < 0.001) as did total macular volume (all Ps < 0.001). Visual acuity was significantly better at 3 and 6 months (P = 0.002) as was the mean macular sensitivity within the three fields (all Ps < 0.05). There were no significant differences in the trend profile of macular thickness and volume within the three fields between the ischemic and nonischemic groups. There were also no significant differences in the trend profile of visual acuity and macular sensitivity.
Intravitreal triamcinolone acetonide may improve macular sensitivity and morphology in patients with ischemic and nonischemic branch retinal vein occlusion.
评估玻璃体内注射曲安奈德治疗视网膜静脉分支阻塞伴黄斑水肿后黄斑敏感性、厚度和总黄斑体积的变化。
17 例视网膜静脉分支阻塞伴黄斑水肿患者的 17 只眼接受了玻璃体内曲安奈德注射。根据荧光素血管造影的毛细血管无灌注情况，将患者分为非缺血性或缺血性组。微视野计用于测量中央 4°、10°和 20°视野内的黄斑敏感性。使用光学相干断层扫描测量这些区域内的黄斑厚度和黄斑体积。
玻璃体内治疗后，中央 4°、10°和 20°视野内的平均黄斑厚度显著降低（均 P < 0.001），总黄斑体积也显著降低（均 P < 0.001）。视力在 3 个月和 6 个月时显著提高（P = 0.002），三个视野内的平均黄斑敏感性也显著提高（均 P < 0.05）。在三个视野内，缺血组和非缺血组的黄斑厚度和体积的趋势分布没有显著差异。视力和黄斑敏感性的趋势分布也没有显著差异。
玻璃体内注射曲安奈德可能改善缺血性和非缺血性视网膜静脉分支阻塞患者的黄斑敏感性和形态。
