DNA synthesis as a therapeutic target: the first 65 years.
作者信息
Mathews Christopher K
机构信息
Department of Biochemistry and Biophysics, 2011 ALS, Oregon State University, Corvallis, OR 97331-7305, USA.
出版信息
FASEB J. 2012 Jun;26(6):2231-7. doi: 10.1096/fj.12-0602ufm.
Abstract
摘要
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Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.胸苷酸合成酶抑制剂对 dUTP 和 TTP 池水平以及 DNA 中尿嘧啶和 5-氟尿嘧啶的 DNA 修复糖苷酶活性的影响。
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Ribonucleotide reductases.核糖核苷酸还原酶
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THE MECHANISM OF ACTION OF 6-MERCAPTOPURINE. I. BIOCHEMICAL EFFECTS.6-巯基嘌呤的作用机制。I. 生化效应。
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Studies on fluorinated pyrimidines. XIII. Inhibition of thymidylate synthetase.氟化嘧啶的研究。十三。胸苷酸合成酶的抑制作用。
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Inhibition of dihydrofolic reductase by aminopterin and amethopterin.氨蝶呤和甲氨蝶呤对二氢叶酸还原酶的抑制作用。
Proc Soc Exp Biol Med. 1958 Feb;97(2):429-31. doi: 10.3181/00379727-97-23764.
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Thymidylate synthase as a translational regulator of cellular gene expression.胸苷酸合成酶作为细胞基因表达的翻译调节因子。
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Mol Pharmacol. 2000 Apr;57(4):695-9. doi: 10.1124/mol.57.4.695.
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