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Saturated free fatty acids: islet β cell "stressERs".

作者信息

Mirmira Raghavendra G

出版信息

Endocrine. 2012 Aug;42(1):1-2. doi: 10.1007/s12020-012-9713-0.

DOI:10.1007/s12020-012-9713-0
PMID:22653726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3709454/
Abstract
摘要

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本文引用的文献

1
An islet in distress: β cell failure in type 2 diabetes.处于困境的胰岛：2型糖尿病中的β细胞功能衰竭
J Diabetes Investig. 2010 Aug 2;1(4):123-33. doi: 10.1111/j.2040-1124.2010.00021.x.
2
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.饱和脂肪酸与 TLR 信号转导在胰岛β细胞功能障碍和胰岛炎症中起连接作用。
Cell Metab. 2012 Apr 4;15(4):518-33. doi: 10.1016/j.cmet.2012.01.023. Epub 2012 Mar 29.
3
Mitochondrial reactive oxygen species (ROS) inhibition ameliorates palmitate-induced INS-1 beta cell death.线粒体活性氧（ROS）抑制可改善棕榈酸诱导的 INS-1β细胞死亡。
Endocrine. 2012 Aug;42(1):107-17. doi: 10.1007/s12020-012-9633-z. Epub 2012 Feb 20.
4
Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18.游离脂肪酸通过诱导细胞周期抑制剂 p16 和 p18 阻断小鼠葡萄糖诱导的β细胞增殖。
Diabetes. 2012 Mar;61(3):632-41. doi: 10.2337/db11-0991. Epub 2012 Feb 14.
5
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.1型糖尿病是如何发展的？：重新审视“他杀”或β细胞自杀的概念。
Diabetes. 2011 May;60(5):1370-9. doi: 10.2337/db10-1797.
6
Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.根据体重增加对饮食诱导肥胖小鼠进行分层的β细胞衰竭：无脂肪变性或β细胞量减少但存在分泌功能障碍和胰岛脂质代谢改变。
Diabetes. 2010 Sep;59(9):2178-87. doi: 10.2337/db09-1452. Epub 2010 Jun 14.
7
Adipose tissue inflammation in obesity and metabolic syndrome.肥胖与代谢综合征中的脂肪组织炎症
Discov Med. 2009 Aug;8(41):55-60.
8
Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.GPR40 缺失可损害体内葡萄糖诱导的小鼠胰岛素分泌，而不影响胰岛内细胞燃料代谢。
Diabetes. 2009 Nov;58(11):2607-15. doi: 10.2337/db09-0362. Epub 2009 Aug 31.
9
The islet beta-cell: fuel responsive and vulnerable.胰岛β细胞：对燃料有反应且易受损。
Trends Endocrinol Metab. 2008 Oct;19(8):285-91. doi: 10.1016/j.tem.2008.07.006. Epub 2008 Sep 6.
10
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.对大鼠进行葡萄糖和脂肪乳剂的周期性交替输注会抑制胰岛中的胰岛素基因表达和Pdx-1结合。
Diabetes. 2008 Feb;57(2):424-31. doi: 10.2337/db07-1285. Epub 2007 Nov 8.