Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
Int J Biol Markers. 2012 Oct 8;27(3):e280-4. doi: 10.5301/JBM.2012.9310.
The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p<0.01). Our results suggest that urinary CSE1L deserves further evaluation for the screening of bladder cancer.
染色体分离 1 样蛋白（CSE1L）在大多数癌症中高表达，并已被证实由肿瘤细胞分泌。我们研究了 CSE1L 在膀胱癌患者尿液中的存在情况。免疫组织化学分析结果显示，膀胱癌标本中 CSE1L 表达较高，而正常膀胱标本中仅在一些细胞中显示出非常微弱的染色。免疫印迹显示 CSE1L 存在于膀胱癌患者的尿液中。在 95%（57/60）的膀胱癌或具有尿路上皮不典型/可疑不典型的患者的尿样中检测到了尿 CSE1L 阳性病例。健康对照组的尿液中未检测到 CSE1L（p<0.01）。我们的研究结果表明，尿 CSE1L 值得进一步评估，以用于膀胱癌的筛查。
