Morinis Julia, Shah Jay, Murthy Prashanth, Fulford Martha
Department of Pediatrics;
Paediatr Child Health. 2011 Jun;16(6):e48-50. doi: 10.1093/pch/16.6.e48.
The incidence of early-onset group B streptococcal (GBS) sepsis in the neonatal population has decreased substantially since the introduction of maternal intrapartum antibiotic prophylaxis and routine prenatal screening. However, these strategies have not reduced the incidence of late-onset GBS infections. Additional research pertaining to the transmission of late-onset GBS infections is required to develop effective preventive methods. The present report describes probable horizontal transmission of late-onset GBS infection among three infants in a neonatal intensive care unit. GBS strain confirmation was based on the microbiological picture, antibiogram and pulsed-field gel electrophoresis. These cases highlight the morbidity associated with late-onset GBS disease and the importance of considering horizontal transmission as an etiological factor in GBS infection in the newborn period. Further studies assessing horizontal transmission in late-onset GBS disease may improve prevention and early intervention.
自实施产妇产时抗生素预防和常规产前筛查以来，新生儿早发型B族链球菌（GBS）败血症的发病率已大幅下降。然而，这些策略并未降低晚发型GBS感染的发病率。需要开展更多关于晚发型GBS感染传播的研究，以制定有效的预防方法。本报告描述了新生儿重症监护病房中三名婴儿之间可能存在的晚发型GBS感染水平传播情况。GBS菌株的确认基于微生物学特征、抗菌谱和脉冲场凝胶电泳。这些病例凸显了晚发型GBS疾病相关的发病率，以及将水平传播视为新生儿期GBS感染病因的重要性。评估晚发型GBS疾病水平传播的进一步研究可能会改善预防和早期干预。
