利用遗传标志物提高甲状腺肿瘤细针穿刺活检的诊断。
Employing genetic markers to improve diagnosis of thyroid tumor fine needle biopsy.
机构信息
Genetic Bases of Thyroid Tumor Laboratory, Division of Genetics, Department of Morphology and Genetics and Division of Endocrinology, Department of Medicine, Federal University of São Paulo, SP, Brazil.
出版信息
Curr Genomics. 2011 Dec;12(8):589-96. doi: 10.2174/138920211798120781.
Abstract
Fine-Needle Aspiration (FNA) is the most widely used and cost-effective preoperative test for the initial evaluation of a thyroid nodule, although it has limited diagnostic accuracy for several types of tumors. Patients will often receive cytological report of indeterminate cytology and are referred to surgery for a more accurate diagnosis. An improved test would help physicians rapidly focus treatment on true malignancies and avoid some unnecessary treatment of benign tumors. This review will discuss current molecular markers that may improve thyroid nodule diagnosis.
摘要
细针穿刺抽吸术（FNA）是目前最广泛使用且经济有效的甲状腺结节术前检查方法，尽管它对某些类型的肿瘤的诊断准确性有限。患者通常会收到不确定细胞学的细胞学报告，并被转介进行手术以获得更准确的诊断。改进的检测方法将有助于医生快速将治疗重点放在真正的恶性肿瘤上，并避免对良性肿瘤进行一些不必要的治疗。这篇综述将讨论可能改善甲状腺结节诊断的当前分子标志物。
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