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CD8 + T细胞：糖皮质激素诱导的肿瘤坏死因子受体相关蛋白起重要作用。

CD8+ T cells: GITR matters.

作者信息

Ronchetti Simona, Nocentini Giuseppe, Petrillo Maria Grazia, Riccardi Carlo

机构信息

Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Tossicologia e Chemioterapia, Università di Perugia, Via del Giochetto, 06100 Perugia, Italy.

出版信息

ScientificWorldJournal. 2012;2012:308265. doi: 10.1100/2012/308265. Epub 2012 Apr 30.

DOI:10.1100/2012/308265
PMID:22654588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3361162/
Abstract

As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8(+) T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8(+) cells, paying particular attention to numerous and recent studies that suggest its crucial role in mouse disease models.

摘要

作为肿瘤坏死因子受体超家族的许多成员之一，糖皮质激素诱导的TNFR相关基因（GITR）主要在免疫系统细胞中发挥多种作用。CD8(+) T细胞是抗病毒和抗肿瘤免疫的关键参与者，并且GITR已被证明是这些细胞产生免疫反应的必需分子。本文的目的是聚焦于GITR在CD8(+) 细胞中的功能，特别关注众多近期研究，这些研究表明其在小鼠疾病模型中的关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/3361162/292396b3a115/TSWJ2012-308265.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/3361162/a535f1966f12/TSWJ2012-308265.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/3361162/292396b3a115/TSWJ2012-308265.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/3361162/a535f1966f12/TSWJ2012-308265.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9091/3361162/292396b3a115/TSWJ2012-308265.002.jpg

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