Le Hellard Stéphanie, Hanson Isabel
Centre for Advanced Study Oslo, Norway.
Front Neurosci. 2012 May 24;6:74. doi: 10.3389/fnins.2012.00074. eCollection 2012.
In June 2011, 70 researchers from the disciplines of cognitive science, genetics, psychology, psychiatry, neurobiology, and computer science gathered in Os, Norway, for the first Imaging and Cognition Genetics meeting. The aim of the conference was to discuss progress, enhance collaboration, and maximize the sharing of resources within this new field. In this Perspective, we summarize the major themes that emerged from ICG 2011. The first is the importance of defining cognitive and imaging phenotypes and endophenotypes suitable for genetic analysis. These can come from differential psychology, cognitive science, structural MRI, tractography, and functional imaging. The second theme is the emergence of new methods for the analysis of complex traits. These include advanced computational and statistical techniques for analyzing complex datasets, and new ways of interpreting data from genome-wide association studies, such as jointly evaluating the contribution of SNPs in specific genes and pathways rather than considering single SNPs in isolation. The final theme is the importance of establishing functional correlates of newly identified genetic variants.
2011年6月,来自认知科学、遗传学、心理学、精神病学、神经生物学和计算机科学等学科的70名研究人员齐聚挪威奥斯,参加首届成像与认知遗传学会议。此次会议的目的是讨论该新领域的进展、加强合作并最大限度地促进资源共享。在这篇观点文章中,我们总结了2011年成像与认知遗传学会议中出现的主要主题。第一个主题是定义适合基因分析的认知和成像表型及内表型的重要性。这些表型可以来自差异心理学、认知科学、结构磁共振成像、纤维束成像和功能成像。第二个主题是分析复杂性状的新方法的出现。这些方法包括用于分析复杂数据集的先进计算和统计技术,以及解释全基因组关联研究数据的新方法,比如联合评估特定基因和通路中单个核苷酸多态性(SNP)的贡献,而不是孤立地考虑单个SNP。最后一个主题是建立新发现的基因变异的功能关联的重要性。