Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine New York, NY, USA.
Front Endocrinol (Lausanne). 2011 Sep 27;2:32. doi: 10.3389/fendo.2011.00032. eCollection 2011.
Growth hormone (GH), a master regulator of somatic growth, also regulates carbohydrate and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 (IGF-1). Data from human and rodent studies reveal the importance of GH in insulin synthesis and secretion, lipid metabolism and body fat remodeling. In this review, we will summarize the tissue-specific metabolic effects of GH, with emphasis on recent targets identified to mediate these effects. Furthermore, we will discuss what role GH plays in obesity and present possible mechanisms by which this may occur.
生长激素（GH）是躯体生长的主要调节因子，它还通过与胰岛素和胰岛素样生长因子-1（IGF-1）的复杂相互作用来调节碳水化合物和脂质代谢。来自人类和啮齿动物研究的数据揭示了 GH 在胰岛素合成和分泌、脂质代谢和体脂肪重塑中的重要性。在这篇综述中，我们将总结 GH 的组织特异性代谢作用，并重点介绍最近确定的介导这些作用的靶标。此外，我们将讨论 GH 在肥胖中的作用，并提出可能发生这种作用的机制。
