Agdeppa D, Macaron C, Mallik T, Schnuda N D
J Clin Endocrinol Metab. 1979 Nov;49(5):726-9. doi: 10.1210/jcem-49-5-726.
The plasma levels of high density lipoprotein cholesterol (HDL-C) were reduced in 16 hyperthyroid female patients compared to 37 euthyroid women (33.5 +/- 8 vs. 51.5 +/- 13 mg/dl (mean +/- SD); P less than 0.001). When 5 patients were restudied after restoration of the euthyroid state, plasma HDL-C increased from 29 +/- 5 to 43 +/- 11.5 mg/dl (P less than 0.05). In addition, in 22 hypothyroid women, HDL-C levels were also diminished compared to the euthyroid group (43.4 +/- 15.5 vs. 51.5 +/- 13 mg/dl; P less than 0.05). Nine patients were restudied after L-T4 replacement therapy; their levels of HDL-C increased but not to a statistically significant degree. The daily administration of 0.3 mg L-T4 to eight normal male volunteers for 1 month did not significantly affect HDL-C levels.
与37名甲状腺功能正常的女性相比，16名甲状腺功能亢进的女性患者的血浆高密度脂蛋白胆固醇（HDL-C）水平降低（33.5±8 vs. 51.5±13 mg/dl（平均值±标准差）；P<0.001）。当5名患者在恢复甲状腺功能正常状态后再次接受检查时，血浆HDL-C从29±5升高至43±11.5 mg/dl（P<0.05）。此外，在22名甲状腺功能减退的女性中，与甲状腺功能正常组相比，HDL-C水平也降低（43.4±15.5 vs. 51.5±13 mg/dl；P<0.05）。9名患者在接受左甲状腺素（L-T4）替代治疗后再次接受检查；他们的HDL-C水平有所升高，但未达到统计学显著程度。对8名正常男性志愿者每日给予0.3 mg L-T4，持续1个月，对HDL-C水平没有显著影响。
