Shirakura R, Matsuda H, Nakata S, Kaneko M, Kawaguchi A, Miyagawa S, Fukushima N, Kitagawa S, Naka Y, Kawashima Y
First Department of Surgery, Osaka University Medical School, Japan.
Eur Surg Res. 1990;22(4):197-205. doi: 10.1159/000129101.
The efficacy of Belzer UW solution was compared to Collins' solution in the preservation of asphyxiated cadaver hearts in a canine model. Donor hearts were stored for 24 h: 2 h of in situ hypothermic (15 degrees C) coronary perfusion plus 22 h of simple immersion in ice-cold solution. Verapamil, propranolol and prostacyclin were used for myocytoprotection in both groups. After orthotopic transplantation, all animals were weaned off bypass without inotropic support. After 1 h, however, the cardiac output was significantly higher in the Belzer UW solution group (128 +/- 28 vs. 67 +/- 13 ml/kg/min, p less than 0.01).
在犬类模型中，比较了Belzer UW溶液和Collins溶液在保存窒息尸体心脏方面的效果。供体心脏保存24小时：2小时原位低温（15摄氏度）冠状动脉灌注，外加22小时简单浸泡在冰冷溶液中。两组均使用维拉帕米、普萘洛尔和前列环素进行心肌保护。原位移植后，所有动物在无正性肌力支持的情况下脱离体外循环。然而，1小时后，Belzer UW溶液组的心输出量显著更高（128±28 vs. 67±13 ml/kg/min，p<0.01）。
