Ankara University, Faculty of Pharmacy, Department of Toxicology, 06100 Tandoğan, Ankara, Turkey.
J Trace Elem Med Biol. 2012 Jun;26(2-3):161-4. doi: 10.1016/j.jtemb.2012.03.008. Epub 2012 Jun 2.
Boric acid and sodium borates have been considered as being "toxic to reproduction and development", following results of animal studies with high doses. Experimentally, a NOAEL of 17.5mg B/kg-bw/day (corresponds to ∼2020 ng boron/g blood) has been identified for the (male) reproductive effects of boron in a multigenerational study of rats, and a NOAEL for the developmental effects in rats was identified at 9.6 mg B/kg-bw/day (corresponds to 1270 ng boron/g blood). These values are being taken as the basis of current EU safety assessments. The present study was conducted to assess the boron exposure under extreme exposure conditions in a boric acid production plant located in Bandırma, Turkey. The mean blood boron concentrations of low and high exposure groups were 72.94 ± 15.43 (48.46-99.91) and 223.89 ± 60.49 (152.82-454.02)ng/g respectively. The mean blood boron concentration of the high exposure group is still ≈ 6 times lower than the highest no effect level of boron in blood with regard to the developmental effects in rats and ≈ 9 times lower than the highest no effect level of boron in blood with regard to the reprotoxic effects in male rats. In this context, boric acid and sodium borates should not be considered as toxic to reproduction for humans in daily life.
硼酸和硼酸钠被认为具有“生殖和发育毒性”，这是基于动物高剂量研究的结果。在一项大鼠多代生殖研究中，实验确定了硼对（雄性）生殖的无观察不良效应水平（NOAEL）为 17.5mg B/kg-bw/天（相当于 ∼2020ng 硼/g 血液），而硼对发育的无观察不良效应水平（NOAEL）为 9.6mg B/kg-bw/天（相当于 1270ng 硼/g 血液）。这些数值被用作当前欧盟安全评估的基础。本研究旨在评估位于土耳其班德尔马的硼酸生产厂在极端暴露条件下的硼暴露情况。低暴露组和高暴露组的平均血液硼浓度分别为 72.94 ± 15.43（48.46-99.91）和 223.89 ± 60.49（152.82-454.02）ng/g。高暴露组的平均血液硼浓度仍约为大鼠发育毒性的硼血液无效应水平的 6 倍，约为雄性大鼠生殖毒性的硼血液无效应水平的 9 倍。在这种情况下，硼酸和硼酸钠不应被认为对人类日常生活中的生殖具有毒性。
