Clinical Pharmaceutical Research Institute, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
J Pharm Biomed Anal. 2012 Nov;70:534-8. doi: 10.1016/j.jpba.2012.04.032. Epub 2012 May 10.
Depression is frequently comorbid with cardiovascular diseases (CVDs), but a full understanding of the mechanisms is still on its way. Chronic unpredictable mild stress (CUMS) model is a commonly used model to mimic clinical depression, here we present a GC/MS-based metabolic profiling approach to investigate myocardial metabolic changes of CUMS SD rats. Principal Component Analysis (PCA) and Partial Least Squares-Discriminant Analysis (PLS-DA) were utilized to reveal differences between the model and control group. This study found that molecules proved cardioprotective involving glutamine (P=0.019) and inosine (P=0.013), fatty acid (9,12-octadecadienoic acid, P=0.002; hexadecanoic acid, P=0.006; octadecanoic acid, P=0.030) which serve as the major energy source of heart and collagen molecule precursor proline (P=0.036) had down-regulated in CUMS model group.
抑郁症常与心血管疾病（CVDs）共存，但对其机制的全面理解仍在进行中。慢性不可预测轻度应激（CUMS）模型是一种常用于模拟临床抑郁症的模型，在这里我们提出了一种基于 GC/MS 的代谢组学方法来研究 CUMS SD 大鼠的心肌代谢变化。主成分分析（PCA）和偏最小二乘判别分析（PLS-DA）用于揭示模型组和对照组之间的差异。这项研究发现，涉及谷氨酰胺（P=0.019）和肌苷（P=0.013）的分子被证明具有心脏保护作用，脂肪酸（9,12-十八碳二烯酸，P=0.002；十六烷酸，P=0.006；十八烷酸，P=0.030）是心脏的主要能量来源，胶原蛋白分子前体脯氨酸（P=0.036）在 CUMS 模型组中下调。
