急性 ST 段抬高型心肌梗死患者行直接经皮冠状动脉介入治疗后入院时贫血、C 反应蛋白和血小板平均体积与短期死亡率的关系。
Impact of admission anemia, C-reactive protein and mean platelet volume on short term mortality in patients with acute ST-elevation myocardial infarction treated with primary angioplasty.
机构信息
School of Medicine, University of Zagreb, Croatia.
出版信息
Clin Biochem. 2012 Nov;45(16-17):1506-9. doi: 10.1016/j.clinbiochem.2012.05.026. Epub 2012 May 31.
OBJECTIVES
To investigate admission anemia, C-reactive protein (CRP) and mean platelet volume (MPV) together as prognostic markers in ST-elevation myocardial infarction (STEMI).
DESIGN AND METHODS
Baseline hemoglobin, CRP and MPV were determined in 543 patients with acute STEMI to whom primary angioplasty was performed and evaluated for short term mortality (30 days).
RESULTS
After multivariate analysis anemia (odds ratio 2.69, 95% confidence interval 1.24-5.86) and CRP (odds ratio 3.40, 95% confidence interval 1.13-10.22) remained significant independent predictors of short-term mortality. Addition of anemia and CRP to PAMI risk score improved prediction of short-term outcome; area under ROC curve rose from 0.76 to 0.87 (p<0.001).
CONCLUSION
Better ability to determine 30-day mortality was obtained when anemia and CRP were incorporated into the PAMI risk score.
目的
探讨入院时贫血、C 反应蛋白（CRP）和平均血小板体积（MPV）联合作为 ST 段抬高型心肌梗死（STEMI）的预后标志物。
设计和方法
对 543 例接受直接经皮冠状动脉介入治疗的急性 STEMI 患者进行基线血红蛋白、CRP 和 MPV 测定，并评估其短期死亡率（30 天）。
结果
多因素分析显示，贫血（比值比 2.69，95%置信区间 1.24-5.86）和 CRP（比值比 3.40，95%置信区间 1.13-10.22）仍然是短期死亡率的独立显著预测因素。将贫血和 CRP 加入到 PAMI 风险评分中，可改善短期预后的预测；ROC 曲线下面积从 0.76 提高到 0.87（p<0.001）。
结论
将贫血和 CRP 纳入 PAMI 风险评分可更好地确定 30 天死亡率。
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